Tumour-microenvironment (TME) comprising of impenetrable inter-communications among stromal cells, tumour cells, cancer-associated blood and lymphatic vessels, pericytes, cancer-associated-fibroblasts, cancer-stem cells and extracellular matrix (ECM) that can substantially impact the onset, spread and progression of cancer metastasis.Metastatic bre

Cultural tightness-looseness represents the degree to which a particular culture possesses strong behavioral norms, and the degree to which members of that culture are likely to sanction individuals who deviate from those norms.While tightness-looseness has been quantified for a large and growing number of countries around the VIOLET world, there a

We use exact enumeration to characterize the solutions of quadratic Plates unconstrained binary optimization problems of less than 21 variables in terms of their distributions of Hamming distances to close-by solutions.We also perform experiments with the D-Wave Advantage 5.1 quantum annealer, solving many instances of up Minerals to 170-variable,

Abstract In recent years, 3D-printing technology to fabricate dental implants has garnered widespread attention due to its patient-specific customizability and cost-effectiveness.This preclinical animal study analyzed the radiographic and histomorphometric outcomes of 3D-printed implants (3DIs) placed immediately after extraction and compared them

BackgroundFrailty is characterised by a reduced resilience to adversity.In this analysis we examined changes in frailty in people aged 50+ before and during a period of austere public spending in Holiday Decorations England.MethodsData from the English Longitudinal Study of Ageing 2002-2018 were analysed.Associations between austerity and frailty w